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House of Blues is on the Strip inside Mandalay Bay, near the south end. In your maps or rideshare app, search "Mandalay Bay" and pick the main Resort and Casino spot, not the parking or Shark Reef pins. Let the app drop you at Mandalay Bay's rideshare area, then follow signs to House of Blues. Parking is paid, and Mandalay Bay is a big property, so it is a real walk to the music hall and leaving earlier makes the night easier.

Parking and prices can change, so it is worth a quick check with the venue before you go.